Paratek's 2026 XHANCE Areas of Interest

Paratek supports research in multiple areas for XHANCE (fluticasone propionate), including but not exclusive to:

   - Effects on Chronic Rhinosinusitis (CRS) Symptoms and/or Quality of Life
   - Use in CRS patients with comorbidities
   - Impact on escalation of CRS treatment (e.g., sinus surgery, use of biologics).

XHANCE Requests for Drug Product for use in IIR

The following formulations are available:

   - XHANCE Exhalation Delivery System with Fluticasone Propionate (93mcg per spray)

Paratek’s 2026 XHANCE IIR Review Meeting Schedule:
- February 24, 2026 (Deadline for Submission, February 10, 2026)
- April 28, 2026 (Deadline for Submission, April 14, 2026)
- June 23, 2026 (Deadline for Submission, June 9, 2026)
- August 25, 2026 (Deadline for Submission, August 11, 2026)
- October 27, 2026 (Deadline for Submission, October 13, 2026)
- December 15, 2026 (Deadline for Submission, December 1, 2026)

For further guidance, please contact your assigned regional Medical Science Director.
If you do not have an assigned regional Medical Science Director, please email IIRsupport@paratekpharma.com for further guidance or questions.